The recent discovery of microRNAs (miRNAs) in unicellular eukaryotes, including miRNAs known previously only from animals or plants, implies that miRNAs have a deep evolutionary history among eukaryotes. This contrasts with the prevailing view that miRNAs evolved convergently in animals and plants. We re‐evaluate the evidence and find that none of the 73 plant and animal miRNAs described from protists meet the required criteria for miRNA annotation and, by implication, animals and plants did not acquire any of their respective miRNA (...) genes from the crown ancestor of eukaryotes. Furthermore, of the 159 novel miRNAs previously identified among the seven species of unicellular protists examined, only 28 from the algae Ectocarpus and Chlamydomonas, meet the criteria for miRNA annotation. Therefore, at present only five groups of eukaryotes are known to possess miRNAs, indicating that miRNAs have evolved independently within eukaryotes through exaptation of their shared inherited RNAi machinery. (shrink)

Fossil organisms offer our only direct insight into how the distinctive body plans of extant organisms were assembled. However, realizing the potential evolutionary significance of fossils can be hampered by controversy over their interpretation. Here, as a guide to evaluating palaeontological debates, we outline the process and pitfalls of fossil interpretation. The physical remains of controversial fossils should be reconstructed before interpreting homologies, and choice of interpretative model should be explicit and justified. Extinct taxa lack characters diagnostic of extant clades (...) because the characters had not yet evolved, because of secondary loss, or because they have rotted away. The latter, if not taken into account, will lead to the spurious assignment of fossils to basally branching clades. Conflicting interpretations of fossils can often be resolved by considering all the steps in the process of anatomical analysis and phylogenetic placement, although we must accept that some fossil organisms are simply too incompletely preserved for their evolutionary significance to be realized. (shrink)

Many of the features that distinguish the vertebrates from other chordates are derived from the neural crest, and it has long been argued that the emergence of this multipotent embryonic population was a key innovation underpinning vertebrate evolution. More recently, however, a number of studies have suggested that the evolution of the neural crest was less sudden than previously believed. This has exposed the fact that neural crest, as evidenced by its repertoire of derivative cell types, has evolved through vertebrate (...) evolution. In this light, attempts to derive a typological definition of neural crest, in terms of molecular signatures or networks, are unfounded. We propose a less restrictive, embryological definition of this cell type that facilitates, rather than precludes, investigating the evolution of neural crest. While the evolutionary origin of neural crest has attracted much attention, its subsequent evolution has received almost no attention and yet it is more readily open to experimental investigation and has greater relevance to understanding vertebrate evolution. Finally, we provide a brief outline of how the evolutionary emergence of neural crest potentiality may have proceeded, and how it may be investigated. BioEssays 30:530–541, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

MicroRNAs are non‐coding regulators of gene expression and key factors in development, disease, and targets for bioengineering. Consequently, microRNAs have become essential elements of already burgeoning draft plant genome descriptions where their annotation is often particularly poor, contributing unduly to the corruption of public databases. Using the Citrus sinensis as an example, we highlight and review common failings of miRNAome annotations. Understanding and exploiting the role of miRNAs in plant biology will be stymied unless the research community acts decisively to (...) improve the accuracy of miRNAome annotations. We encourage genome annotation teams to do it right or not at all. (shrink)

This paper has two goals: (1) to defend a particular response to the problem of resultant moral luck and (2) to defend the claim that we are only responsible for what we could have avoided. Cases of overdetermination threaten to undermine the claim that we are only responsible for what we could have avoided. To deal with this issue, I will motivate a particular way of responding to the problem of resultant moral luck. I defend the view that one's degree (...) of responsibility is immune to moral luck but the scope of events for which one is responsible is subject to moral luck. I will then argue that this view allows us to explain away certain intuitions about responsibility and overdetermination (as well as similar intuitions regarding Frankfurt Cases). As a result, the claim that we are only responsible for what we could have avoided becomes significantly more plausible. (shrink)

A theory of the first-person plural occupies a unique place in philosophical investigations into intersubjectivity and social cognition. In order for the referent of the first-person plural—“the We”—to come into existence, it seems there must be a shared ground of communicative possibility, but this requires a non-circular explanation of how this ground could be shared in the absence of a pre-existing context of communicative conventions. Margaret Gilbert’s and John Searle’s theories of collective intentionality capture important aspects of the We, but (...) fail to fully account for this shared ground of communicative possibility. This paper argues that Merleau-Ponty’s concept of intercorporeity helps reconcile the positive aspects of these accounts while also explaining how the genesis of the social world is continuous with perceptual life in general. This enables an account of the first-person plural as dependent on reciprocal communicative interaction without the need to posit a primitive or primordial “we-mode” of consciousness. “Intercorporeity” designates a bodily openness to others that is not fundamentally different in kind from the general style of bodily comportment found in Merleau-Ponty’s rich analyses of perceptual life. (shrink)

This volume contains nine chapters of translation, by a range of leading scholars, focusing on core themes in the philosophy of Zhu Xi (1130-1200), one of the most influential Chinese thinkers of the later Confucian tradition. -/- Table of Contents: Chapter One: Metaphysics, Epistemology, and Ethics by Philip J. Ivanhoe Chapter Two: Moral Psychology and Cultivating the Self by Curie Virág Chapter Three: Politics and Government by Justin Tiwald Chapter Four: Poetry, Literature, Textual Study, and Hermeneutics by On-cho Ng (...) Chapter Five: Social Conditions of His Time by Beverly Bossler Chapter Six: Heaven, Ghosts and Spirits, and Ritual by Hoyt Tillman Chapter Seven: Criticisms of Buddhism, Daoism, and the Learning of the Heart-mind by Ellen Neskar and Ari Borrell Chapter Eight: Science and Natural Philosophy by Yung Sik Kim Chapter Nine: Zhu Xi's Commentarial Work: Abiding in the Mean and the Constant by Daniel Gardner. (shrink)

The phenomenon of contract cheating presents, potentially, a serious threat to the quality and standards of Higher Education around the world. There have been suggestions, cited below, to tackle the problem using legal means, but we find that current laws are not fit for this purpose. In this article we present a proposal for a specific new law to target contract cheating, which could be enacted in most jurisdictions.We test our proposed new law against a number of issues that would (...) need to be considered before any legal approach could be successful; would changing the legal status of contract cheating make it less likely to happen? Could this be achieved in a specific way? If so, who should actually be prosecuted and what offence are they committing? Would it actually address the causes of contract cheating? We suggest some answers to these questions, but then also identify a number of unintended potential consequences. We therefore additionally consider whether a legal approach is possible or even desirable.We conclude that a legal approach to contract cheating is possible, and, on balance, appropriate. Using UK law as an example, we offer a specific suggestion to lawmakers, around the world, for how this might be achieved, and conclude that the most successful approach would be to focus largely on a law targeting the providers of contract cheating, in particular commercial services. (shrink)

Although the push to get universities to accumulate IP by commercializing their scientific research was a conscious movement, dealing with the blowback in the form of contracts over the transfer of research tools and inputs, called materials transfer agreements (MTAs), was greeted by universities as an afterthought. Faculty often regarded them as an irritant, and TTOs were not much more welcoming. One reason universities could initially ignore the obvious connection between the pursuit of patents and the prior promulgation of MTAs (...) was a legalistic distinction made between intellectual property and contract law, which of course is of direct concern to a lawyer, but should be less compelling for anyone trying to understand the big picture surrounding the commercialization of academic science. However, as a subset of scientists were increasingly drawn into the commercial sphere, they tended to attach MTAs to research inputs requested by other academics; and this began a tidal wave of MTAs which shows no sign of abating. Furthermore, many IP-related restrictions have been loaded into individual MTAs, including the stipulation that the existence and content of MTAs themselves be treated as secret and proprietary. The paper closes by looking at recent arguments that the growth of MTAs has not actually harmed the research process, and rejects them. (shrink)

Physicalism dominated Anglo‐American philosophy in the latter half of the twentieth century, and is perhaps still the most popular view among analytic philosophers. Panpsychism is increasingly being seen as a serious option, both for explaining consciousness and for providing a satisfactory theory of the natural world. Perhaps the most popular form of panpsychism at present is constitutive panpsychism. At least some fundamental material entities are conscious; facts about human and animal consciousness are grounded in facts about the consciousness of their (...) fundamental material parts. This chapter equates panpsychism with constitutive panpsychism. In considering responses to the notorious combination problem for panpsychism, the chapter moves onto other forms of panpsychism to examine whether they fare any better against this challenge. It adopts the via negativa definition of physicalism. Panqualityism is the only form of panprotopsychism which offers a clear positive proposal as to what protophenomenal properties are. (shrink)

A and B continue their conversation concerning the Identity of Indiscernibles. Both are aware of recent critiques of the principle that haven’t received replies; B summarizes those critiques, and A offers the replies that are due. B then raises a new worry.

Do citizens have an obligation to obey the law? This book differs from standard approaches by shifting from the language of obedience to that of deference. The popular view that law claims authority but does not have it is here reversed on both counts: law does not claim authority but has it. Though the focus is on political obligation, the author approaches that issue indirectly by first developing a more general account of when deference is due to the view of (...) others. Two standard practices that political theorists often consider in exploring the question of political obligation - fair-play and promise-keeping - can themselves be seen as examples of a duty of deference. In this respect the book defends a more general theory of ethics whose scope extends beyond the question of political obligation to questions of duty in the case of law, promises, fair play and friendship. (shrink)

In explicit memory recall and recognition tasks, elaboration and contextual isolation both facilitate memory performance. Here, we investigate these effects in the context of sentence processing: targets for retrieval during online sentence processing of English object relative clause constructions differ in the amount of elaboration associated with the target noun phrase, or the homogeneity of superficial features (text color). Experiment 1 shows that greater elaboration for targets during the encoding phase reduces reading times at retrieval sites, but elaboration of non-targets (...) has considerably weaker effects. Experiment 2 illustrates that processing isolated superficial features of target noun phrases --- here, a green word in a sentence with words colored white --- does not lead to enhanced memory performance, despite triggering longer encoding times. These results are interpreted in the light of the memory models of Nairne 1990, 2001, 2006, which state that encoding remnants contribute to the set of retrieval cues that provide the basis for similarity-based interference effects. (shrink)

Delusions are currently characterised as false beliefs produced by incorrect inference about external reality (DSM IV). This inferential conception has proved hard to link to explanations pitched at the level of neurobiology and neuroanatomy. This paper provides that link via a neurocomputational theory, based on evolutionary considerations, of the role of the prefrontal cortex in regulating offline cognition. When pathologically neuromodulated the prefrontal cortex produces hypersalient experiences which monopolise offline cognition. The result is characteristic psychotic experiences and patterns of thought. (...) This bottom-up account uses neural network theory to integrate recent theories of the role of dopamine in delusion with the insights of inferential accounts. It also provides a general model for evolutionary psychiatry which avoids theoretical problems imported from evolutionary psychology. (shrink)

Rationing is an unavoidable mechanism for reining in healthcare costs. It entails establishing cutoff points that distinguish between what is and is not offered or available to patients. When the resource to be distributed is defined by vague and indeterminate terms such as “beneficial,” “effective,” or even “futile,” the ability to draw meaningful boundary lines that are both ethically and medically sound is problematic. In this article, I draw a parallel between the challenges posed by this problem and the ancient (...) Greek philosophical conundrum known as the “sorites paradox.” I argue, like the paradox, that the dilemma is unsolvable by conventional means of logical analysis. However, I propose another approach that may offer a practical solution that could be applicable to real-life situations in which cutoffs must be decided (such as rationing). (shrink)

Chairman Hua emphasized in his speech last year at the opening ceremony of the Central Party School that: "Chairman Mao instructed us over and over that ‘the integration of theory and practice is the most fundamental principle of Marxism.’ Chairman Mao fought all his life against the evil work style of boasting and of separating theory from practice. … Political swindlers such as Lin Biao, Chen Boda, and the "gang of four" have messed up many basic theoretical issues and damaged (...) our Party's good learning style. We must make a tremendous effort to correct that.". (shrink)

What is the criterion of truth? This is a question that was resolved long ago by the revolutionary teachers of the proletariat. But as a result of damage done by the "Gang of Four" and a mass of distorted propaganda in the media under their control, it has become muddled beyond compare in recent years. In order to deepen the criticism of the "Gang of Four" and eradicate the remnants of their poison and influence, it is very important to clear (...) this up and sort it out. (shrink)

Goodchild offers a philosophical analysis of the contemporary economy in terms of the way it structures credit and faith.

We review some recent developments in the conformal gravity theory that has been advanced as a candidate alternative to standard Einstein gravity. As a quantum theory the conformal theory is both renormalizable and unitary, with unitarity being obtained because the theory is a PT symmetric rather than a Hermitian theory. We show that in the theory there can be no a priori classical curvature, with all curvature having to result from quantization. In the conformal theory gravity requires no independent quantization (...) of its own, with it being quantized solely by virtue of its being coupled to a quantized matter source. Moreover, because it is this very coupling that fixes the strength of the gravitational field commutators, the gravity sector zero-point energy density and pressure fluctuations are then able to identically cancel the zero-point fluctuations associated with the matter sector. In addition, we show that when the conformal symmetry is spontaneously broken, the zero-point structure automatically readjusts so as to identically cancel the cosmological constant term that dynamical mass generation induces. We show that the macroscopic classical theory that results from the quantum conformal theory incorporates global physics effects that provide for a detailed accounting of a comprehensive set of 138 galactic rotation curves with no adjustable parameters other than the galactic mass to light ratios, and with the need for no dark matter whatsoever. With these global effects eliminating the need for dark matter, we see that invoking dark matter in galaxies could potentially be nothing more than an attempt to describe global physics effects in purely local galactic terms. Finally, we review some recent work by ’t Hooft in which a connection between conformal gravity and Einstein gravity has been found. (shrink)

Ovidians continue to be puzzled by the 404-line speech put into the mouth of Pythagoras in book 15 of theMetamorphoses.Questions of literary decorum and quality are insistently raised: how does the philosopher's popular science consort with the predominantly mythological matter of the preceding fourteen books? Do Pythagoras' revelations provide some kind of unifying ground, a ‘key’, for the endless variety of the poem? Can one take the Speech as a serious essay in philosophical didactic, or is it all a mighty (...) spoof, as intentionally laughable, perhaps, as the imperial panegyric with which the narrative of book 15 concludes? Or should we beware of imposing modern tastes on Ovid's original audience, and respect the Hellenistic and Roman predilection for scientific poetry? This article seeks to establish further contexts for the evaluation of the Speech of Pythagoras through a study of Ovid's allusive practice within the Greco-Roman tradition of hexameterepos.The figure who provides a foundation for Ovid's construction of his own poetic genealogy turns out to be the Greek philosophical poet Empedocles. The resulting reflections on Ovid's manipulation of generic conventions may be timely in the light of the recent appearance of sophisticated and fresh approaches to the question of whether theMetamorphosesis, or is not, an epic. (shrink)

Professors of media ethics are open in a unique position to help a plaint i f i n a libel trial, and under certain circumstances they may even have a moral duty to do so. But the decision to testifyfor a plaintlfcomes with certain problems built i n for professors who depend on local media outlets for student practicum experiences and employment ofgraduates. In the end, professors who decide to testify both for and against the media depending on the facts (...) of the case are involved in a teaching process that is a natural extension of what they do in the classroom. (shrink)

Why are some patients with Parkinson's disease unhappy about the outcome of deep brain stimulation (DBS)? Meccaci and Haselager (2014) attempt to answer this question by analyzing the seminal case...

People can look at non-conforming behaviour in two ways: either the person is acting immorally or the moral theory that condemns the behaviour is mistaken. To choose the former is to reflect a confidence in the existing moral theory, while choosing the latter is evidence that moral theory for that particular behaviour is wrong. This point says a lot about the link between the descriptive and evaluative enterprises of law. The development of basic moral principles, which draws from moral intuition, (...) is a similar process when it comes to developing social practices, which in turn draw from human behaviour. Legal positivism has contributed much to clarifying the kind of social facts that characterize legal systems, specifically the kind of normative claims that legal systems typically make. Legal positivism provides much of the descriptive front. This chapter is motivated by an interest in reconciling the normative claims of law with the claims that moral philosophers believe can be justified. (shrink)

Angela Mendelovici’s book The Phenomenal Basis of Intentionality is a paradigm-establishing monograph within the phenomenal intentionality research program. Mendelovici argues that extant theories of intentionality that do not appeal to consciousness are both empirically and metaphysically inadequate, and a coherent, consciousness-based alternative can adequately explain (or explain away) all alleged cases of intentionality. While I count myself a fellow traveler, I discuss four choice-points where Mendelovici has taken, I believe, the wrong fork. (1) The explanatory relation that holds between intentional (...) and phenomenal properties is not identity but realization. (2) The mechanism that generates derivatively representational states is not content self-ascription but neural re-wiring. (3) The source of semantic structure within phenomenal-intentional states is not external structure and/or second-order co-instantiation but primitive phenomenal ascription. (4) The mode of presence of contents within phenomenal-intentional states is not being part of a superficial characterization, but being monadically present as an intentional object. (shrink)

Once the notion of a precursive relationship between developmental stages is fully articulated in terms of the distinction between ‘role’ and ‘realiser’ states, it turns out that the ‘Theory of Mind’ literature operates with a notion of precursive relationships described at too high a level of abstraction to explain actual mechanisms of development. Furthermore, the tendency within that literature to explain precursive relationships in terms of role states with isomorphic linguistic/computational structures is misleading. Developmental relationships are more likely to exist (...) between states which play a similar normative role in the agents’s psychology than between states which can be described as sharing a similar computational architecture. (shrink)

The ArgumentMany find it “notoriously difficult to see how societal context can affect in any essential way how someone solves a mathematical problem or makes a measurement.” That may be because it has been a habit of western scientists to assert their numerical schemes were untainted by any hint of anthropomorphism. Nevertheless, that Platonist penchant has always encountered obstacles in practice, primarily because the stability of any applied numerical scheme requires some alien or external warrant.This paper surveys the history of (...) measurement standards, physical dimensions and dimensionless constants as one instance of the quest to purge all anthropomorphic taint first in the metric system, then in the dimensions provided by the atom, then in physical constants intelligible to extraterrestrials, only then to end up back at overt anthropomorphism in the late 20th century. This suggests that the “naturalness” of natural numbers has always been conceptualized in locally contingent cultural terms. (shrink)

The publication of volume 2 of Philip T. Grier’s translation of _The Philosophy of Hegel as a Doctrine of the Concreteness of God and Humanity _completes the first appearance in English of any of the works of Russian philosopher I. A.Il’in. Most of the contents of volume 2 will be unknown even to those who have read the 1946 German version prepared by Il’in, because in that version he omitted eight of the original ten chapters. These omitted chapters provide (...) an extended reflection on the central categories of Hegel’s moral, legal, and political philosophies, as well as of the philosophy of history. The topics examined are, in order: freedom, humanity, will, right, morality, ethical life, personhood and its virtue, and the state. Contained within these chapters are some notably insightful expositions of core doctrines in Hegel’s philosophy. Il’in’s colleague A. F. Losev accurately observed in the same year the text first appeared: “Neither the study of Hegel nor the study of contemporary Russian philosophical thought is any longer thinkable without this book of I. A. Il’in’s.”. (shrink)

John Conington was a towering figure in Victorian scholarship, not least because of his remarkably sensitive and literate commentaries on Virgil’s _Aeneid. _The three-volume cloth edition of _The Works of Virgil_, begun by Conington in 1852, has been unavailable for over a century, except in rare second-hand sets. Now, for the first time, the whole of Conington’s work is being reissued in a set of six paperback volumes. Each volume includes a new introduction by an established scholar, setting Conington's commentary (...) in context, as well as a general introduction to Conington’s work by Philip Hardie, who offers a fresh appreciation of the work. (shrink)

The philosophies of Merleau-Ponty and the later Wittgenstein are shown to yield a common position opposing 'realist' attempts to reduce appearance, sense, and meaning to perception-independent objects and relations. Their 'Gestalt Philosophy' thus constitutes a new form of 'anti- realism'.

This book is a collection of essays on the Parallel Lives of the Greek philosopher and biographer Plutarch which examines the moral issues Plutarch recognized behind political leadership, and places his writings in their political and social context of the reigns of the Flavian emperors and their successors.

'A brilliant, utterly persuasive argument for genuine democracy in our own country...The proposals...are bound to be inspiring to anyone who takes politics, in the largest sense of the word, seriously.'-Barbara Ehrenreich.

The Nature of Concepts examines a central issue for all the main disciplines in cognitive science: how the human mind creates and passes on to other human minds a concept. An excellent cross-disciplinary collection with contributors including Steven Pinker, Andy Clarke and Henry Plotkin.

For many years women tended to vote more conservative than men, but since the 1980s this gap has shifted direction: women in many countries are more likely than men to support left parties. The literature largely agrees on a set of political-economic factors explaining the change in women’s political orientation. In this article we demonstrate that these conventional factors fall short in explaining the gender vote gap. We highlight the importance of a religious cleavage in the party system across Western (...) European countries, restricting the free flow of religious voters between left and right parties. Given that surveys show us a constantly higher degree of religiosity among women and a persistent impact of religion on vote choice, religion explains a substantial part of the temporal as well as cross-country variation in the transition from the more conservative to the more progressive voting behavior of women. (shrink)

God Beyond Orthodoxy: Process Theology for the 21stcentury.

Scholarly use of the label “school” to describe groups of philosophers has sometimes led to a neglect of the ways in which such gatherings of philosophers could function as unofficial associations of recognizable types. Concerns to distance supposedly “secular” philosophers from any “religious” connection have fed into this image of the philosophical “school,” diverting attention away from other important dimensions of associative life among philosophers and other literate professionals, including involvement in honours for the gods and in commensal activities. Epigraphic (...) evidence helps to elucidate the broader associative context. The fact that some philosophers formed associations has implications for adjacent fields, such as Christian origins, where there is a tendency to ask whether groups of Jesus followers were socially analogous to a Judean synagogue, an association, or a philosophical school, as though these were distinct options rather than overlapping social phenomena. Such associations of relatively literate people were among the few in antiquity that can also be described using the scholarly category of “reading communities.”. (shrink)